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Hong Kong Flu

Hong Kong Flu was a pandemic outbreak of influenza A (H3N2) which occurred in 1968-69. This virus was first detected in Hong Kong in early 1968 and spread to the United States later that year where it caused about 34,000 deaths, making it the mildest pandemic in the 20th century.

There could be several reasons why fewer people in the US died due to this virus. First, the Hong Kong flu virus was similar in some ways to the Asian flu virus that circulated between 1957 and 1968. Earlier infections by the Asian flu virus might have provided some immunity against the Hong Kong flu virus that may have helped to reduce the severity of illness during the Hong Kong pandemic.

Second, instead of peaking in September or October, like pandemic influenza had in the previous two pandemics, this pandemic did not gain momentum until near the school holidays in December. Since children were at home and did not infect one another at school, the rate of influenza illness among schoolchildren and their families declined.

Because of its similarity to the 1957 Asian Flu (which was the H2N2 strain, differing from the Hong Kong flu only in the chemical arrangement of the hemagglutinin protein as a result of antigenic shift) and possibly the subsequent accumulation of related antibodies in the affected population, the Hong Kong flu resulted in much fewer casualties than most pandemics. Casualty estimates vary: between 750,000 and two million people died of the virus worldwide (34,000 people in the United States) during the two years (1968-1969) that it was active. It was therefore the least lethal pandemic in the 20th century.

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